The 3000 block of South Commercial Avenue will be closed starting on Wednesday, April 20, according to the city of Madison.
South Commercial is the frontage road between Webb Avenue and Rethke Avenue on the city's far east side.
Officials said the the closure is due to emergency road repairs.
The road will be closed through Friday, April 22.
Access to businesses will remain open from Webb Avenue and Rethke Avenue, city officials said.
Motorists are encouraged to use different routes to avoid delay during this project.